Publications of 2014
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P. Jeffrey Conn, Craig W. Lindsley, Jens Meiler, Colleen M. Niswender
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
Nature Reviews Drug Discovery
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Huixian Wu, Chong Wang, Karen J. Gregory, Gye Won Han, Hyekyung P. Cho, Yan Xia, Colleen M. Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov, P. Jeffrey Conn, Raymond C. Stevens
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
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Holger Jaeschke, Joerg Schaarschmidt, Markus Eszlinger, Sandra Huth, Rudolf Puttinger, Olaf Rittinger, Jens Meiler, Ralf Paschke
A newly discovered TSHR variant (L665F) associated with non-autoimmune hyperthyroidism in an Austrian family induces constitutive TSHR activation by steric repulsion between TM1 and TM7
Journal of Clinical Endocrinology & Metabolism
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Holger Jaeschke, Joerg Schaarschmidt, Markus Eszlinger, Sandra Huth, Rudolf Puttinger, Olaf Rittinger, Jens Meiler, and Ralf Paschke
A Newly Discovered TSHR Variant (L665F) Associated With Nonautoimmune Hyperthyroidism in an Austrian Family Induces Constitutive TSHR Activation by Steric Repulsion Between TM1 and TM7
The Journal of Clinical Endocrinology and Metabolism
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Sandeepkumar Kothiwale, Corina M. Borza, Edward W. Lowe Jr, Ambra Pozzi and Jens Meiler
Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery
Drug Discovery Today
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Kevin K. Kumar, Edward W. Lowe, Jr., Asad A. Aboud, M. Diana Neely, Rey Redha, Joshua A. Bauer,Mihir Odak, C. David Weaver, Jens Meiler, Michael Aschner, Aaron B. Bowman
Cellular manganese content is developmentally regulated in human dopaminergic neurons
Scientific Reports
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Ali I Kaya, Alyssa D. Lokits, James A. Gilbert, Tina M. Iverson, Jens Meiler, Heidi E. Hamm
A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit
Journal of Biological Chemistry
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Xavier Pedragosa-Badia, Gregory R. Sliwoski, Elizabeth Dong Nguyen, Diana Lindner, Jan Stichel, Kristian W. Kaufmann, Jens Meiler
Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y4 Receptor Binding Pocket
Journal of Biological Chemistry
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John P. Donahue, Rebecca T. Levinson, Jonathan H. Sheehan, Lorraine Sutton, Harry E. Taylor, Jens Meiler, Richard T. D'Aquila, Chisu Song
Genetic Analysis of the Localization of APOBEC3F to Human Immunodeficiency Virus Type 1 (HIV-1) Virion Cores
Journal of Virology
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Claudia Doberenz, Michael Zorn, Dörte Falke, David Nannemann, Doreen Hunger, Lydia Beyer, Christian H. Ihling, Jens Meiler, Andrea Sinz, R. Gary Sawers
Pyruvate Formate-Lyase Interacts Directly with the Formate Channel FocA to Regulate Formate Translocation
Journal of Molecular Biology
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Karen Joan Gregory, Elizabeth D Nguyen, Chrysa Malosh, Jeffrey L Mendenhall, Jessica Z Zic, Brittney S Bates, Meredith J Noetzel, Emma F Squire, Eric M Turner, Jerri M. Rook, Kyle A Emmitte, Shaun R. Stauffer, Craig W Lindsley, Jens Meiler, and P. Jeffrey Conn
Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site
ACS Chemical Neuroscience
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Philip Lossl, Knut Ko¨lbel, Dirk Ta¨nzler, David Nannemann, Christian H. Ihling, Manuel V. Keller, Marian Schneider, Frank Zaucke, Jens Meiler, Andrea Sinz
Analysis of Nidogen-1/Laminin γ1 Interaction by Cross-Linking, Mass Spectrometry, and Computational Modeling Reveals Multiple Binding Modes
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Aleksandra Margeti?, David Nannemann, Jens Meiler, Daniel Huster, Stephan Theisgen
Guanylate Cyclase-Activating Protein-2 Undergoes Structural Changes upon Binding to Detergent Micelles and Bicelles
Biochimica et Biophysica Acta (BBA) - Biomembranes
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Thomas Austin, David P. Nannemann, Sam DeLuca, Jens Meiler, Eric Delpire
In silico Analysis and Experimental Verification of OSR1 Kinase - Peptide Interaction
Journal of Structural Biology
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Kathleen F. Mittendorf, Brett M. Kroncke, Jens Meiler, Charles R. Sanders
The Homology Model of PMP22 Suggests Mutations Resulting in Peripheral Neuropathy Disrupt Transmembrane Helix Packing
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Veronika Made, Dr. Kathrin Bellmann-Sickert, Anette Kaiser, Prof.?Dr. Jens Meiler, Prof.?Dr. Annette G. Beck-Sickinger
Position and Length of Fatty Acids Strongly Affect Receptor Selectivity Pattern of Human Pancreatic Polypeptide Analogues
Not available Van Hoveln, R. J., Schmid, S. C.; Tretbar, M.; Buttke, C.; Schomaker, J. M.
Formal Asymmetric Hydrobromination of Styrenes via Copper-Catalyzed 1,3-Halogen Migration
Chemical Science
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Alexander Sevy, Jens Meiler
Antibodies: Computer-Aided Prediction of Structure and Design of Function
Microbiology Spectrum