Group Members


David Nannemann

Former Post-Doctoral Fellow

B.S., Hardin-Simmons University
david.p.nannemann [ at ]

Research Interests:

Enzymes perform an interesting array of chemical reactions but are  limited by substrate specificities. Computational methods allow for  quick in silico screening of multi-mutant enzymes easing the burden in  the wet-lab. Work is oriented towards application of RosettaLigand to  switch substrate specificity and impart catalytic function on novel, non-natural substrates.

  • Research Projects
  • Publications
David P. Nannemann;Kristian Kaufmann, Jens Meiler, Brian Bachmann
Design and directed evolution of a dideoxy purine nucleoside phosphorylase (2010) Protein Engineering

Mohammed S. Aiyegbo;Gopal Sapparapu, Benjamin W. Spiller, Ilyas M. Eli, Dewight R. Williams, Robert Kim, David E. Lee, Tong Liu, Sheng Li, Virgil L. Woods Jr, David P. Nannemann, Jens Meiler, Phoebe L. Stewart, James E. Crowe Jr
Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore (2013) PLOS One

Steven A Combs;Samuel L DeLuca, Stephanie H DeLuca, Gordon H Lemmon, David P Nannemann, Elizabeth D Nguyen, Jordan R Willis, Jonathan H Sheehan, Jens Meiler
Small-molecule ligand docking into comparative models with Rosetta (2013) Nature Protocols

Thornburg NJ;Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, Meiler J, Crowe JE Jr.
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses (2013) J Clin Invest

Natalie J. Thornburg;David P. Nannemann, David L. Blum, Jessica A. Belser, Terrence M. Tumpey, Shyam Deshpande, Gloria A. Fritz, Gopal Sapparapu, Jens C. Krause, Jeong Hyun Lee, Andrew B. Ward, David E. Lee, Sheng Li, Katie L. Winarski, Benjamin W. Spiller, Jens Meiler, and James E. Crowe, Jr.
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses (2013) J Clin Invest

Thomas Austin;David P. Nannemann, Sam DeLuca, Jens Meiler, Eric Delpire
In silico Analysis and Experimental Verification of OSR1 Kinase - Peptide Interaction (2014) Journal of Structural Biology

Claudia Doberenz;Michael Zorn, Dörte Falke, David Nannemann, Doreen Hunger, Lydia Beyer, Christian H. Ihling, Jens Meiler, Andrea Sinz, R. Gary Sawers
Pyruvate Formate-Lyase Interacts Directly with the Formate Channel FocA to Regulate Formate Translocation (2014) Journal of Molecular Biology

Philip Lossl;Knut Ko¨lbel, Dirk Ta¨nzler, David Nannemann, Christian H. Ihling, Manuel V. Keller, Marian Schneider, Frank Zaucke, Jens Meiler, Andrea Sinz
Analysis of Nidogen-1/Laminin γ1 Interaction by Cross-Linking, Mass Spectrometry, and Computational Modeling Reveals Multiple Binding Modes (2014) PLOSOne

Aleksandra Margeti?;David Nannemann, Jens Meiler, Daniel Huster, Stephan Theisgen
Guanylate Cyclase-Activating Protein-2 Undergoes Structural Changes upon Binding to Detergent Micelles and Bicelles (2014) Biochimica et Biophysica Acta (BBA) - Biomembranes

Brett M. Kroncke;Wade D. Van Horn, Jarrod Smith, CongBao Kang, Richard C. Welch, Yuanli Song, David P. Nannemann, Keenan C. Taylor, Nicholas J. Sisco, Alfred L. George Jr., Jens Meiler, Carlos G. Vanoye, Charles R. Sanders
Structural basis for KCNE3 modulation of potassium recycling in epithelia (2016) Science Advances