Group Members


Maik Tretbar

Current research Professor

PhD in Organic Chemistry, University of Hamburg, Germany
maik.tretbar [ at ]
Leipzig University - Bruederstrasse 34

Research Interests:

  • Organic Synthesis
  • Medicinal and Pharmaceutical Chemistry
  • Natural product synthesis
  • Method Development (Catalysis)
  • NMR structure determination
  • X-ray crystallography of small molecules


Maik is currently team leader of the ChemCore / Tretbar Lab at the Institute for Drug Discovery at Leipzig University.

Synthesis of small molecules developing a pipeline of selective inhibitors aimed by regulation of DNA expression. Natural product isolation of antimicrobial compounds, structural characterization, and their selective oxo-functionalization to improve solubility and bioactivtiy against antibiotic resistant bacteria. Synthesis of biopharmaceutical products including the implementation of catalytic methods to approach new scaffolds. The Medicinal Synthetic Chemistry Core is part of the new institute and responsible for the synthesis of potentially bio-active compounds based on the computational results predicting a high binding affinity to the proteins' active sites. Large-scale synthesis of organic compounds, development of valid analytics based on GC-MS (FID), HPLC-DAD and structure determination via NMR-spectroscopy and X-ray crystallography.

Research: in progress



Organic Chemistry I:This course (11-PHA-0201) introduces students to the chemistry of carbon-containing compounds. Organic chemistry is at the heart of biology and medicine: pharmaceuticals, proteins, carbohydrates, fats, and DNA are all organic compounds.

Organic Chemistry II: Chemistry of carbon & its importance to biological molecules (11-PHA-0301). Topics include current ideas of bonding & structure, reaction mechanisms, a discussion of the analytical tools used to determine the structure and stereochem. of organic compounds (IR, NMR).


  • Research Projects
  • Publications
Lukas von Bredow;Lukas von Bredow, Thomas M. Schäfer, Julian Hogenkamp, Maik Tretbar, Daniel Stopper, Fabian K. Kraft, Julian Schliehe-Diecks, Andrea Schöler, Arndt Borkhardt, Sanil Bahitia, Jana Held, Finn K. Hansen
Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin-HDAC Inhubitor Hybrids as Multitarget Drugs (2022) Pharmaceuticals

Tretbar, Maik;Witzel, Thomsen; Hauffe, Anika; Junghans, Ulrike; Bulc, Ales; Pufky-Heinrich, Daniela
Feasibilty study on the etherification of fermentative-produced isobutylene to fully renewable ethyl tert-buytl ether (ETBE). (2018) Catalysts

Maik Tretbar;Christian B. W. Stark
Large-Scale Synthesis of Symmetric Tetramine Ligands by Using a Modular Double Reductive Amination Approach (2017) European Journal of Organic Chemistry

Nels C Gerstner;Christopher S Adams, Maik Tretbar, Jennifer M Schomaker
Stereocontrolled Syntheses of Seven-Membered Carbocycles by Tandem Allene Aziridination/[4+3] Reaction (2016) Angewandte Chemie

Gerstner, N. C.;Adams, C. S.; Grigg, R. D.; Tretbar, M.; Rigoli, J. W.; Schomaker, J. M
Diastereoselective Synthesis of the Aminocyclitol Core of Jogyamycin via an Allene Aziridination Strategy (2016) Organic Letters

Van Hoveln, R. J.;Schmid, S. C.; Tretbar, M.; Buttke, C.; Schomaker, J. M.
Formal Asymmetric Hydrobromination of Styrenes via Copper-Catalyzed 1,3-Halogen Migration (2014) Chemical Science

Alexander J. K. Roth;Maik Tretbar, Christian B. W. Stark
Chemical Communications (2015) Chemical Communications