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Meiler Lab Computational Chemical and Structural Biology |
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Rocco Moretti
Current Research Professor
PhD in Biochemistry, University of Wisconsin, USA
rmorettiase [ at ] gmail.com
Vanderbilt University - MBRIII 5140 Office Suite
Research Interests:
- Rosetta
- Method Development
- Drug Design
- Ligand Docking
- Enzyme Design
- Protein-Small Molecule Interaction
- Foldit
Computational design of biological systems promises to revolutionize the way we investigate and treat diseases, as well as how we approach materials engineering and chemical synthesis. I'm interested in developing methodologies to allow facile design of new biological systems, particularly those involving protein/small-molecule interactions. Currently I'm investigating structure-based techniques to allow us to propose new drug-like small molecules, which are designed to bind a given protein system. The hope is that such a general design system will allow straightforward creation of drug leads for systems involved in a range of diseases.
- Research Projects
- Publications
Rearrangement of the extracellular domain/extracellular loop 1 interface is critical for thyrotropin receptor activation (2016) J. Biol. Chem.
Tessmer MH;Anderson DM, Pickrum AM, Riegert MO, Moretti R, Meiler J, Feix JB, Frank DW
Identification of a ubiquitin-binding interface using Rosetta and DEER. (2018) Proc Natl Acad Sci U S A
Moretti R;Bender BJ, Allison B, Meiler J
Rosetta and the Design of Ligand Binding Sites. (2016) Methods Mol Biol.
Moretti R;Lyskov S, Das R, Meiler J, Gray JJ
Web-accessible molecular modeling with Rosetta: The Rosetta Online Server that Includes Everyone (ROSIE). (2018) Protein Sci.
Brian J. Bender;Alberto Cisneros, Amanda M. Duran, Jessica A. Finn, Darwin Fu, Alyssa D. Lokits, Benjamin K. Mueller, Amandeep K. Sangha, Marion F. Sauer, Alexander M. Sevy, Gregory Sliwoski, Jonathan H. Sheehan, Frank DiMaio, Jens Meiler, and Rocco Moretti
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts (2016) Biochemistry